mRNA Process Development Scientist [Belgium]

 

eTheRNA immunotherapies was founded in 2013. eTheRNA has established an integrated set of proprietary capabilities for an end-to-end solution to design, develop and manufacture next-generation mRNA products based on enabling technologies. eTheRNA’s business model will utilize this suite of capabilities to provide superior products for partners in both early-stage research as well as later-stage development for mRNA therapeutics. eTheRNA will leverage its proprietary molecular designs, lipid biochemistry expertise, customized lipid nanoparticle formulations (cLNPs), mRNA-based T cell adjuvants, and advanced manufacturing processes to overcome the current challenges facing the development of mRNA therapeutics. By expanding its significant expertise in designing, synthesizing, and manufacturing cLNPs with a spectrum of properties suitable for a range of prophylactic and therapeutic indications, this innovative business model will allow the company to accelerate near-term revenue growth through technology licensing and mRNA cGMP manufacturing services for multiple future partners.

www.etherna.be | www.ethernamanufacturing.com

https://www.etherna.be/

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General job description

The mRNA Process Development Scientist is a hands-on person who will work collaboratively on further development of medicinal product formulations based on mRNA as well as the further improvement of the mRNA production process. This position provides also input on the implementation, optimization and validation of new (innovative) methods.

This position reports into the Senior Scientist Product Development and will be based in Niel.

Responsibilities and Duties

The mRNA Process Development Scientist’s duties shall include, but not be limited to:

• Primary responsibilities will be to perform, in close collaboration with the Head of Product Development, a variety of routine and specialized mRNA production processes as required. Develop processes from first principles as required or optimize existing processes where specified
• Develop new upstream and downstream processes as required for CDMO clients or collaboration partners.
• Maintain an innovative approach to process development by maintaining knowledge of state of the art process techniques and equipment and use knowledge to input into improved process design which may lead to IP generation.
• Participate in process tech transfer operations as SME for internal or external transfers. Ensure good collaboration with the Tech Transfer team.
• Work collaboratively with outside resources (e.g. contract labs and experts, CDMO clients, external collaboration partners).
• Generate analytical data on process operations as required using external labs or internal analytical development or QC resource.
• Maintain appropriate files related to ongoing experiments. Write process experimental protocols and reports. Maintain a detailed electronic lab book
• Help to troubleshoot experimental techniques, analyzing the data and reporting the experimental results
• Participate in the maintenance and cleaning of equipment and lab areas
• Inventory management and ordering of laboratory supplies
• Coordinate activities of a small team of Research Associates in order to meet the goals described above
• Good awareness of the company’s EHS policies and strict adherence to procedures at all times

Job requirements

Education:

MS in Pharmaceutical/Biomedical/Biological Sciences or related field

Experience:

• Minimum of 2 to 4 years of relevant laboratory or manufacturing experience (can be both academic or industrial)
• Broad technical expertise and mastering of several molecular biology techniques, upstream process techniques including bioreactor operation, column chromatography techniques and filtration processes
• Broad and detailed knowledge of nucleic acids
• Working knowledge of good manufacturing practices (GMP) and lab quality assurance practices is a plus

Other Qualifications, Skills and Abilities:

• Detail-oriented and accurate in following instructions, record keeping and completion of reports
• Able to perform experimental trouble-shooting and propose technical solutions
• Scientific integrity
• Good knowledge of English
• Good communication skills
• Well organized, well-structured, hands-on, result focused
• Able to work under stringent time lines
• Ability to foster teamwork and a collaborative atmosphere
• Enthusiastic, flexible and able to multitask
• Understanding of MS Office (Excel, Word, PowerPoint, Outlook)

Our offer

• An varied job in a dynamic and enterprising environment where you can learn a lot
• Employment contract of unlimited duration with a competitive salary package, including benefits
• Working in a fun team where collaboration and innovation are central

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